Milnacipran drug is widely used as an antidepressant. After purchasing Milnacipran without prescription, you may use it not only for the depressive disorders elimination, but also to relieve the fibromyalgia symptoms.
Milnacipran belongs to the class of antidepressants from the group of “selective serotonin and noradrenaline reuptake inhibitors” (SNRI). Reduced concentration of these two major mediators in the body increases the hypersensitivity of the central nervous system and the perception of pain.
Fibromyalgia may result from the lowering of norepinephrine and serotonin concentrations. It is a complex disease that is manifested in chronic pain sensations throughout the body and is accompanied by anxiety disorders, sleep disorders and chronic fatigue.
Cognitive-behavioral therapy (CBT) and a set of physical exercises are used at the initial stage of the fibromyalgia treatment. However, the disease treatment may be complemented by the use of such antidepressants, as Milnacipran, if these methods have proved ineffective.
The mechanism of Milnacipran action is not completely understood. Though, it is assumed that this antidepressant is able to retain and increase serotonin and norepinephrine concentration in the neural connections of the brain. Increasing the concentration of serotonin exerts an antidepressant effect, while as norepinephrine reuptake – an analgesic one.
Milnacipran is unique due to the fact that it inhibits the norepinephrine reuptake approximately three times stronger than that of serotonin. This indicates that the analgesic effect of Milnacipran is more pronounced than the antidepressant.
After oral administration, Milnacipran is well absorbed and has an almost absolute bioavailability. Peak of the therapeutic activity occurs in about 2-4 hours after the intake. Sustained concentrations of this antidepressant persist in the body for a half to two days.
This antidepressant should be taken once or twice a day to relieve the symptoms of fibromyalgia. If you bought Milnacipran without prescription, take it at the same time of the day. Meals do not affect Milnacipran bioavailability, but may improve the tolerability of the drug.
The initial antidepressant dose on the first day of Milnacipran use is 12.5 mg. The dose is increased to 25 mg per day and is divided into two intakes during the next two days.
In the next two or three days of treatment with this antidepressant, the daily dose of Milnacipran amounts to 25 mg twice a day. Milnacipran dose may be increased to 100 mg per day, divided into two doses, after a week of this antidepressant use. Daily Milnacipran doses of 200 mg should be taken only in case of serious fibromyalgia symptoms manifestation.
A sharp discontinuation of Milnacipran treatment may result in withdrawal symptoms: headache, irritability, anxiety, as well as numbness or tingling in the extremities. Gradual reduction in Milnacipran dosage should be inversely proportional to its increase.
The advantages of Milnacipran:
- it has a high selectivity to serotonin and norepinephrine;
- unlike tricyclic antidepressants (TCAs), it only affects serotonin and noradrenaline receptors;
- due to the high selectivity, it causes significantly fewer side effects and is better tolerated than other antidepressants.
By ordering Milnacipran online without prescription, you get a safe and effective antidepressant that is much cheaper than in the city pharmacies.
Although Milnacipran is an antidepressant, it may not be used only as a sedative. The antidepressant is also not capable of completely curing fibromyalgia. Milnacipran is only effective in relieving the symptoms of this disease.
Milnacipran was developed in France in 1996 and was originally used for relieving the symptoms of severe depressive disorders. Over time, the antidepressant appeared on sale in more than 45 countries around the world.
On January 2, 2008, the US pharmaceutical company Cypress Bioscience has submitted an application to the FDA for Milnacipran approval exclusively for fibromyalgia symptoms elimination. On January 15, 2009, the FDA approved a new drug under the brand name Savella. Each tablet contained 12.5, 25, 50 and 100 mg of Milnacipran.
Buying Milnacipran online is absolutely legal. However, before selling Milnacipran without prescription, online pharmacies must provide consultations by medical professionals. Such consultations are necessary for the most correct and safe use of Milnacipran.