Lyrica is a drug, used as an antidepressant, an anesthetic agent, and as an anticonvulsant. Patients with epilepsy, depressive disorders or experiencing pain due to the nervous system lesions, may buy Lyrica without prescription.
The active ingredient of Lyrica is Pregabalin. This is an analogue of gamma-aminobutyric acid (GABA) – the most important inhibitory neurotransmitter, regulating the function of the brain and the nervous system. The GABA analogue binds irreversibly to the brain receptors, responsible for seizure activity.
The analgesic and antidepressant effects of Lyrica are provided by binding to the spinal cord receptors. They are bound particularly in the structures that are significant for pain transmission. The analogue of GABA suppresses the pain impulses in the nerve endings.
Unlike other AEDs, Lyrica reduces the release of neurotransmitters in pathology only and remains passive in no pain impulses. The drug neither affects the neurotransmitter systems, nor provides other effects.
Upon ingestion, Pregabalin is quickly absorbed in the gastrointestinal tract. The maximum concentration is achieved in 60 minutes after the administration, while the half-life lasts about 6 hours.
If you are planning to buy Lyrica without prescription on the online pharmacy, select one of two formulations of this anti-epileptic drug:
- Lyrica capsules of 25, 50, 75, 100, 150, 200, 225, 300 mg;
- ingestion solution Lyrica 20 mg/ml.
Lyrica may be taken two or three times a day, irrespectively of meals.
Lyrica is an effective and reliable remedy for relief of neuropathic pain. This type of pain is caused not by external influences, but by hyperactivity of neurons in the central nervous system. Neuropathic pain is expressed as numbness, stabbing and acute pain and burning sensation.
To relieve the symptoms of neuropathic pain or depression, patients should take 150 mg of Lyrica per day. A week later, provided for a good tolerability, the daily analgesic dose may be increased to 300 or 450 mg. Only in urgency, the daily dose of Lyrica may reach 600 mg.
Lyrica may be used to relieve seizures and epilepsy as supportive therapy to anticonvulsants. Dosage of Lyrica is the same as for neuropathic pain: in the first week – 150 mg a day, 7 days later- 300 mg daily, and 600 mg per day – in the third week of the drug application.
Lyrica may be used to relieve fibromyalgia symptoms. It is a chronic musculoskeletal pain in the entire body, accompanied by sleep and depressive disorders.
Fibromyalgia treatment with the analgesic should be started with 75 mg of Lyrica a day. If pain symptoms still remain in a week of the analgesic application, the daily dose is to be increased to 450 mg. A week later, a Lyrica dose can be increased to 600 mg per day, if necessary.
The advantages of Lyrica application:
- Lyrica efficacy remains even in long-term use;
- symptomatic relief of neuropathic pain in the first three days of the analgesic application;
- symptoms relief in neuropathic pain, epilepsy, fibromyalgia in patients with no response to other drugs.
Lyrica application should be stopped within at least one week, by gradually reducing the dosage. A sudden cessation of Lyrica may cause withdrawal symptoms, such as seizures.
When ordering Lyrica without prescription, you may be sure that you buy the drug meeting all the criteria for the neuropathic pain relief:
- safe even in overdose;
- no psychotropic effect;
- easy and convenient scheme of the dose selection;
- no interaction with liver enzymes;
- blocking calcium channels in the central nervous system.
At the same time, Lyrica is a bit inferior by its anticonvulsant action to another popular anticonvulsant – Gabapentin. This anticonvulsant is also a GABA derivative. Yet, Gabapentin rarely causes side effects, and they are milder comparing to Lyrica.
Lyrica was the first Pregabalin-based drug. This agent was developed in 1990 by Richard Bruce Silverman at Northwestern University, Chicago State, USA. The drug was developed as an improved formula of Gabapentin. However, the new drug was investigated for a long time.
At the beginning of 2004, the Pregabalin-based drug was approved in the European Union, and in the same December, the drug was approved by the FDA. In the autumn of 2005, this anticonvulsant appeared in the USA pharmaceutical market under the brand name of Lyrica.
In June 2007, Lyrica was the first drug in the USA, approved for relief of fibromyalgia symptoms. Within one year, Lyrica held the status of the only drug for fibromyalgia treatment in the USA, until Cymbalta, a new drug based on Duloxetine, was approved in June 2008.
Lyrica is available without prescription, not only in the US online pharmacies but on pharmacies that deliver anti-epileptic medicines in Australia, Canada, Finland, Ireland, Philippines, South Africa, Sweden, Kuwait, South Africa, Guatemala and other countries of the world.