Pristiq is a drug used to treat the symptoms of severe and chronic depression. Patients exposed to major depressive disorder (MDD) may order Pristiq online without prescription.
Pristiq reduces the severity of depression symptoms due to Desvenlafaxine. It is a synthetic derivative of Venlafaxine and is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). These are the two most important neurotransmitters, the concentration of which influences emotions and mood, as well as sleep regulation and stress response.
Pristiq prevents the reuptake of serotonin and norepinephrine from the points of the neural connections of the brain connections. Increased concentrations of these neurotransmitters alter the emotional perception, enhance your mood and improve your health.
Pristiq is highly selective. This antidepressant only affects serotonin and noradrenaline receptors. Other receptors groups are not covered by Pristiq activity. Thus, Pristiq is safer than other antidepressants for the elimination of the MDD symptoms.
Only a healthcare professional should assess the feasibility of its application and select the dosage of this antidepressant. Pristiq is absolutely contraindicated for use without a confirmed MDD diagnosis.
You should start the treatment with this antidepressant with a minimum Pristiq dose of 50 mg daily. Pristiq tablets should be taken once a day at the same time, regardless of meals. Pristiq doses of 100 to 400 mg per day may be equally effective in eliminating the symptoms of depression, without negative consequences for the body.
Daily Pristiq doses may vary from 25 to 100 mg per day in patients with liver or kidney problems. Patients in this category may take the antidepressant not on a daily basis, but every other second day.
The daily Pristiq dose of 25 mg is recommended for phasing out the antidepressant. Gradual decrease of Pristiq dosage is recommended for avoiding potential side effects or withdrawal symptoms.
The advantages of Pristiq:
- it does not cause significant side effects;
- Pristiq significantly reduces the risk of the depressive disorder relapse;
- it is superior by its efficacy and safety to other groups of antidepressants, like tricyclic antidepressants (TCAs) or selective serotonin reuptake inhibitors (SSRI).
Despite the high efficiency and safety, Pristiq may cause undesirable reactions. Side effects may often be contributed by the patients themselves. Having purchased Pristiq without prescription, many people start giving this anti-depressant to children under 18 years of age, or combine Pristiq with alcohol.
Pristiq is the first Desvenlafaxine-based drug. It was created specifically to enhance the effectiveness of other antidepressant – Venlafaxine. Application for Pristiq approval was submitted to the FDA in 2006 by the pharmaceutical company Wyeth.
In 2007, the FDA requested additional clinical trials on the efficacy and safety of this antidepressant. After complying with all the conditions and confirming the drug safety, Pristiq finally received the FDA approval on March 3, 2008.
Clinical trials for Pristiq efficiency revealed that in addition to the antidepressant effect, the drug also alleviates women’s condition during menopause. Repeated attempts have been made in this regard to get the approval for Pristiq as a means for eliminating hot flashes and sweats during menopause. Yet, Pristiq is intended solely for the MDD symptoms facilitation up until now.
Wyeth Company was acquired by Pfizer in 2009, and since then all the rights for Pristiq supplies and sale belong to Pfizer. According to the data of 2010, the volume of Pristiq sales in the USA totaled $ 439 million. A year later, the sales volume of this antidepressant rose by another 24%.
You may easily buy this antidepressant online. The official website of the manufacturer offers patients to buy Pristiq without prescription after filling a special consumer form.
Patients are also given a cumulative coupon, which allows saving money on Pristiq purchases in the amount of up to $ 75 each month. However, only the USA residents have the possibility to purchase Pristiq without prescription from the official supplier.
In other countries, such as Canada, Brazil, Chile, Mexico, Spain, Argentina or Australia you may buy Pristiq in numerous online pharmacies. The price of this antidepressant depends on the country of residence and the choice of a particular online pharmacy.