Tramadol 50 mg

Tramadol-containing will help you get rid of moderate to severe chronic pain symptoms. Adult patients may buy analgesics, based on Tramadol, without prescription online.

Tramadol belongs to the class of analgesics, called “opioid receptor agonists”. Tramadol is close to Codeine by the analgesic potential. The analgesic effect of Tramadol is exerted due to the activation of a certain group of opioid receptors.

However, the mechanism of Tramadol analgesic action is not completely identical to the mechanism of other opioid agonists’ action. Unlike other opiates, Tramadol affects not only the opioid receptors, but the serotonin noradrenaline receptors, as well.

Each of Tramadol mechanisms of action affects the activity of opioid and non-opioid receptor to a rather weak extent. Yet, this painkiller doesn’t simply provide an analgesic effect for each group of receptors. It promotes a multiple enhancement of the general analgesic effect.

Tramadol is rapidly absorbed after the oral administration. Its analgesic effect occurs within 15-30 minutes and lasts 4-8 hours. The maximum plasma concentration is observed 1.5-2 hours after the intake. Half-life may vary from 4 to 5 hours.

Both conventional and the online pharmacies offer the following dosage forms of Tramadol:

  • oral solution of 100 mg/ml;
  • capsules of 50 mg, 100 mg, 200 mg and 300 mg;
  • orally disintegrating tablets (ODT) 50 mg;
  • injection or infusion of 50 mg/1 ml and 100 mg/2 ml;
  • tablets with the immediate and extended (ER) release of 50 mg, 100 mg, 150 mg, 200 mg, 300 mg and 400 mg.

Patients, who require urgent relief from acute attacks of severe pain, should buy ODT Tramadol without prescription. A single dose may vary from 50 to 100 mg every 4-6 hours. However, the total daily dose of Tramadol should not exceed 400 mg.

Patients with severe chronic pain may start taking this analgesic with a dose of 50 mg ODT once a day. Then, the dose may be increased by 50 mg of Tramadol every three days, and the number of intakes may be brought to 3-4 per day. The maximum daily dose of Tramadol may be 200 mg, divided into four intakes.

Unlike ODT, which you may take several times a day, the conventional Tramadol tablets and capsules should be taken once a day. The initial dose is 100 mg of Tramadol per day. The daily dose of the analgesic may be increased every 3-5 days by 100 mg to achieve a balance between the analgesic tolerance and the pain symptoms relief.

IF you order Tramadol tablets and capsules online without prescription, note that they should only be taken by patients aged 17 and more. Intravenous or intramuscular administration of Tramadol painkiller may be used for children under the age of 12 years.

The advantages of Tramadol:

  • due to the double action mechanism – on non-opioid and opioid receptors – the analgesic effect is achieved more quickly;
  • lack of pronounced side effects, characteristic of other central action opioid analgesics;
  • the minimum probability of the resistance and drug dependence development in prolonged use.

Tramadol originally belonged to the narcotic analgesic drugs. Yet, numerous experimental and clinical studies have shown later almost a total lack of ability to cause psychic and physical dependence.

If you are using Tramadol, you may notice only minor side effects – dry mouth, nausea or dizziness. Yet, all these adverse reactions usually bring no discomfort during the study or work, and do not affect the ability to drive a vehicle.

Tramadol may rarely cause insomnia, apathy or dysphoria. This avoids the concomitant prescribing of other pharmacological classes – benzodiazepines, antidepressants and neuroleptics.

Tramadol is a unique pharmaceutical development, since it has a dual mechanism of action. It was first synthesized in 1962 by the German pharmaceutical company Gruenenthal GmbH. The first Tramadol-based analgesic went on sale in 1972 under the brand name Tramal.

Since the 1970s, Grünenthal GmbH has sold the rights to sell this analgesic to many pharmaceutical companies. Today, Tramadol is available for sale in more than 100 countries around the world. There are about 55 brand names of drugs that contain Tramadol.

Currently, Tramadol-containing drugs are available for sale in such countries, as the USA, the UK, Chile, the New Zealand, Nigeria, Sweden and many others. Ordering Tramadol without prescription online or buying it in a conventional pharmacy is absolutely legal. Tramadol has the lowest risk of dependence out of all synthetic opioid analgesics.