Percocet is a combined drug, which will help you get rid of moderate to severe pain symptoms. This analgesic provides a systematic approach to pain elimination. You may buy Percocet without prescription at any online pharmacy.
The analgesic effect of Percocet is achieved due to the two active ingredients – Oxycodone and Acetaminophen. The first component is a centrally acting narcotic analgesic that acts on opioid receptors in the brain and the central nervous system.
Acetaminophen, also known as Paracetamol or APAP (Acetyl-Para-Aminophenol) is a non-narcotic analgesic of peripheral action, and is one of Percocet components, intended for enhancing the analgesic effect of Oxycodone. Acetaminophen has no effect on the brain. It acts only in the central nervous system by inhibiting the activity of enzymes that cause pain.
Individual use of each of these analgesics, of central and peripheral action, is not always enough to provide a pronounced analgesic effect. A dosage increase may lead to side effects and toxicity buildup.
This fact predisposed the creation of Percocet, the combined analgesic, which became a perfect mixture of the two central and peripheral action components. Choosing Percocet allows not only to achieve adequate analgesia, but also to reduce the risk of side effects due to low doses of each component.
The combination of both central and peripheral analgesic action explains the breadth of Percocet application. The combined medication may be used for getting rid of pain symptoms of various origins, from chronic to postoperative pain.
Each Percocet component has a different time for reaching the maximum plasma concentration: about 1 hour for Paracetamol, and 2.5-3 hours for the opioid analgesic. Based on the pharmacokinetic Percocet characteristics, its use is justified: Paracetamol acts faster, while as Oxycodone exerts its action later and ensures a prolonged analgesic effect.
Percocet dosage is selected depending on the symptoms severity, pain intensity and analgesic tolerance. Since the analgesic dosage is adjusted individually for each patient, Percocet tablets may contain very different amounts of the active ingredients – 2,5 to 10 mg of Oxycodone and 325 to 650 mg of Acetaminophen.
The maximum Percocet dose may vary from 6 to 12 tablets a day. Intervals between the analgesic doses should last at least 6 hours. This is exactly the time period, during which a single Percocet tablet maintains its analgesic effect.
The patient should not start self-treatment after buying Percocet without prescription. This analgesic should be used only under the supervision of your doctor or any other health professional.
The combination of the two active ingredients provides Percocet with high efficacy in eliminating pain symptoms. Despite this, many patients who buy Percocet without prescription make common mistakes in its administration:
- divide one tablet into multiple doses;
- abruptly discontinue the analgesic;
- do not comply with regular administration regime;
- take more pills than needed for the analgesic effect.
- uncontrolled use of Percocet with other analgesics (Norco, Vicodin), or the central nervous system stimulants, such as alcohol.
These and other errors of patients on Percocet may lead to dangerous side effects, drug dependence or withdrawal syndrome. You should use this combined drug very carefully and follow all the recommendations for its use.
Percocet was not the first drug, based on the combination of an opioid and a non-narcotic analgesic. The first such combined drug appeared in the second half of the 1950s and was called Percodan. However, one significant disadvantage was the inability to use Percodan for postoperative pain treatment because of its high toxicity.
Percocet was approved in the USA in 1976 as an adequate substitute for Percodan. This combined analgesic quickly started gaining popularity among the USA population as an effective analgesic means. The pharmaceutical company Endo Pharmaceuticals has been engaged in the production and supply of Percocet in the territory of the USA since 2006.
Yet, the FDA restricted the sales of Percocet and other opioid-containing combined analgesics in June 2009. Restriction on Percocet sale was introduced due to the high risk of an overdose and drug dependence.
In spite of everything, Percocet remains one of the most commonly prescribed analgesics in the USA. Another country, in which you may buy Percocet without prescription, is Canada. However, just like in the USA, sales of this combined analgesic are limited.