Tapentadol-based drugs are used as effective analgesics. Patients with moderate to severe pain symptoms are enough to order Tapentadol-containing analgesics online without prescription to get rid of them.
The analgesic activity of Tapentadol is associated with the activity inhibition of opioid receptors, which are the most important pain regulators. Therefore, Tapentadol belongs to the class of analgesic drugs called “opioid analgesics”.
By its effect on opioid receptors in, Tapentadol analgesic activity is similar to Morphine effects. Although this analgesic is significantly inferior to Morphine in the strength of its analgesic effect, Tapentadol does not cause significant side effects or drug dependence, characteristic of Morphine.
Yet, in addition to the opioid receptors agonism, Tapentadol exerts another action. It inhibits the reuptake of norepinephrine. This neurotransmitter simulates the pain signals, and its accumulation in the brain receptors reduces the patient’s sensitivity to pain.
Norepinephrine is capable not only of changing the pain perception. Increased concentration of this neurotransmitter improves the stability and sensitivity to stress. Thus, Tapentadol contributes not only to the analgesic, but also to the antidepressant effect at a certain degree.
After the ingestion, Tapentadol reaches the maximum plasma concentration in after about 1-2 hours. The therapeutic effect of the drug develops since its first application.
Tapentadol without prescription is available for sale in two dosage forms:
- immediate or extended release (ER) tablets of 25, 50, 75, 100, 150, 200 or 250 mg;
- oral solution of 4 mg/ml or 20 mg/ml.
Tapentadol administration and dosage regimen depends on many factors.
When a patient begins Tapentadol therapy, he should stop using other opioid analgesics. While the dosage calculations are available for other opiate in combined use, Tapentadol should be taken only as a monotherapy.
Tapentadol dose should be taken every 4-6 hours, when you use the immediate release tablets of this analgesic. Two ER tablets of this analgesic are enough for a daily administration.
If Tapentadol is the patient’s first opioid analgesic, his daily dose is 100 mg of Tapentadol, divided into two doses. For patients, who do not tolerate the action of analgesic, Tapentadol dose may be 25 mg twice a day.
Patient that uses immediate release Tapentadol tablets may switch to ER tablets at any time. For example, if the patient took 50 mg of Tapentadol four times a day, he may switch to administering 100 mg ER tablets twice a day.
When you order Tapentadol online without prescription, note that only a healthcare professional may decide on the use of this analgesic and the dosage increase. Regardless of the dosage form – tablets or solution – the daily dose of Tapentadol should not exceed 700 mg.
Tapentadol is the first drug with mixed effects – analgesic and antidepressant. It was first synthesized in the 1980s, by Helmut Buschmann, who worked in the German pharmaceutical company Grünenthal.
The analgesic was created as an adequate substitute for Tramadol, another painkiller. Tapentadol was qualitatively different from its predecessor by not affecting serotonin receptors.
In the USA, this opioid analgesic was approved on November 21, 2008. The immediate release tablets were called Nucynta and contained 50, 75 and 100 mg of Tapentadol Hydrochloride. Three years later, on August 25, 2011, ER Nucynta tablets appeared on the market in addition to the conventional ones. Johnson & Johnson Company was engaged in the supply of this analgesic to the pharmaceutical market in the US.
On June 23, 2009, Tapentadol was listed in Schedule II at the request of the Drug Enforcement Administration (DEA). This meant that all of the drugs, based on this opioid analgesic are under the supervision due to the high risk for abuse.
Currently, Nucynta remains the only Tapentadol-based drug, which is sold in the USA. You may Tapentadol without prescription in other countries under the brand name Palexia. The opioid analgesic is sold in such countries, as Australia, Spain, Germany, the UK and India.
Despite the increased risk of abuse, drugs based on Tapentadol continue to be used as effective pain relievers. Before you buy Tapentadol online without prescription, you should read the opinions of other patients on this analgesic.
For example, you may find a lot of reviews about Tapentadol on the website of the nonprofit educational organization Erowid. Members share their experiences and describe in detail the entire process of this opioid analgesic use.